In 2 Samuel 7, God promised David that there would be one of David's seed upon his throne unto all... generations. David wondered at this, and asked if this were the way of man.
Since David's throne was ended in Jerusalem in the time of Zedekiah, king of Judah, in the time of Jeremiah the prophet, when Nebuchadnezzar, king of Babylon came upon Jerusalem and destroyed it, and then killed all of Zedekiah's male heirs, and Zedekiah died in Babylon, David's throne has never been re-established there in Jerusalem to this day.
Because of that, most preachers today deem that our Heavenly Father was pointing to Lord Jesus sitting upon David's throne in Heaven, which in reality is not Biblical, because we are shown Jesus is now sitting on the 'right hand of The Father's throne' in Heaven, not David's throne which is an 'earthly throne'.
Also, the Genesis 49:10 prophecy that Jacob gave his son Judah for the 'last days', reveals Judah is to keep that royal rule all the way up to the day when Jesus returns ("Shiloh" being a symbol there for Jesus' future return). This further establishes that God's promise to David that there would never fail a man to sit upon David's throne is STILL in effect somewhere upon this earth, even today.
Of course God's enemies do not like to hear about this. Especially since Satan's host consider themselves the true rulers of this present world. Nevertheless, this is Bible prophecy, and God has said it, and what He says He will do, will come to pass. And it has.
When Jeremiah escaped captivity to Babylon under Nebuchadnezzar, the way it happened per the Book of Jeremiah is he was taken captive by bandits into Egypt. God had told the Israelites not to try and escape to Egypt, but to go captive to Babylon and He promised to take care of them. But Jeremiah, being kinsman redeemer to the royal family, was guardian of the "king's daughters", and were taken captive to Tahpanhes, Egypt per Jeremiah 43.
In the Book of Jeremiah, God said He ordained Jeremiah a prophet over the 'nations',
"to root out, and to pull down, and to destroy, and to throw down, to build, and to plant." (Jeremiah 1:10).
The rooting out, destroying, and throwing down was about Nebuchadnezzar, king of Babylon, destroying Jerusalem and taking the "house of Judah" captive to Babylon for seventy years.
But what about that part God said that Jeremiah was chosen also to do,
"to build, and to plant"? Just where... did God accomplish that through Jeremiah? It certainly was not... in the holy land, because Jeremiah, the king's daughters with him, and his scribe Baruch, were all taken captive into Egypt, and they all then drop out of Bible history.
But can we 'depend' upon God accomplishing what He said through Jeremiah, about that "to build, and to plant"? Yes. It's simply a matter of studying and understanding what God had promised about the nations, like Ephraim's seed who was to become "a multitude of nations" per the Genesis 48 blessing by Jacob (Israel).
That "multitude of nations" prophecy to Ephraim's seed directly involves the scattered ten tribes of Israel. Biblically, and historically (per the Jewish historian Josephus), the ten northern tribes of Israel (minus Judah, Benjamin, and Levi), were removed to Assyria and the lands of the Medes by the kings of Assyria, about 120 years prior... to Judah's captivity to Babylon under Nebuchadnezzar. In those lands the ten tribes remained and never returned to the holy lands. They lost their heritage as part of Israel, like God had prophesied through His prophet Hosea. And they were further scattered out of Assyria, to the West, into Asia Minor and Europe. In the Assyrian tablets, documentation by the ancient Assyrians in their royal correspondence refer to the ten tribes of Israel using certain names, like Khumri, derived from king Omri one of the kings of Israel (northern kingdom of ten tribes after the split of 1 Kings 11). The names Cimmerians and Scythians became labels for the ten tribes in their scattering around the Black Sea into Europe. One of the passages through the Caucasus mountains above the Black Sea was known as the Dariel pass.
Per prophecy in Genesis 48 to Ephraim, his seed was to become "a multitude of nations", and his brother Manasseh also was to become "great". That was originally a prophecy God gave to Jacob (Israel) back in Genesis 35 that Jacob's seed was to become "a nation, and a company of nations". And Jacob in Genesis 48 said to let his name (Israel) be named upon the two lads (Ephraim and Manasseh).
We know that the nation of Israel through history has always been but 'one' nation, not a multitude of nations. So when and where was this "multitude of nations" prophecy fulfilled, or has it been fulfilled yet?
What is even more interesting, is Ephraim's relationship with the ten northern tribes of Israel after God split the old kingdom of Israel into two separate kingdoms per 1 Kings 11. Jeroboam, one born of the tribe of Ephraim, was selected by Solomon as governor over the northern ten tribes when Solomon was king. They then later had a falling out, and Jeroboam fled to Egypt fearing his life. Then because of Solomon rebelling against God by allowing his many wives to bring idol worship in among Israel, God rent the kingdom from Solomon, but promised to do it in his son's day, Rehoboam, Solomon's son.
At that time, when God rent the kingdom from Solomon and his son Rehoboam; Jeroboam (of Ephraim) returned, and God ordained Jeroboam as "king of Israel" (meaning the northern kingdom, which was called Israel because of the majority of the tribes lived in the northern lands. This did not include the Jews that made up the southern "kingdom of Judah" at Jerusalem-Judea). This history is written in 1 Kings 11.
Jeroboam was not of the tribe of Judah, which only one born of Judah of the house of David was to be king over Israel per God's ordaining. So what gives with that, since God is Who made Jeroboam king over Israel after the split?
Do you recall the story about Joseph and his eleven brethren, and how Jacob favored Joseph more than his brothers, and this made his brothers jealous? So they took Joseph, put him in a pit to decide what to do with him. Then Medianite merchants found Joseph and sold him as a slave into Egypt. Joseph's brothers then told their father that Joseph was dead. But God exalted Joseph in Egypt to second in charge of all Egypt. And during a famine, Joseph's brethren came to Egypt to buy grain, and Joseph disguised himself, so his brethren would not realize who he was. But in final, Joseph revealed himself to his brethren, and they were all joined together as a family again, but in Egypt, and prospered into a great many people there. Likewise with Ephraim and Manasseh, they represent an ordeal like what Joseph went through, being separated from their brethren of the "house of Judah" (Jews) which remained in the holy land at the time of the ten tribes being removed by the kings of Assyria (2 Kings 17).
Thus the "house of Israel" (ten northern tribes) and the "house of Judah" (Jews at Jerusalem-Judea), were separated by God splitting up old Israel into two separate kingdoms, and then scattered the majority of both houses, leaving only a small remnant of Jews (Judah, Benjamin, and Levi) at Jerusalem. This is why today only the Jews are know as the people of Israel. The greater majority of Israelites which were scattered, have been lost; they are lost to the Jews and to the world (Yet God said He would keep a remnant that would know the truth). These scattered Israelites lost knowledge of their heritage as children of Israel. They took on Gentile habits and customs, and became as Gentiles living among Gentiles. But God has not forgotten them, and has promised to gather both houses back together (Ezekiel 37 about the two sticks being put back together in the future).
Thusly, today's split of the two 'houses' in God's Word is similar to Joseph's separation in Egypt, with his brethren not recognizing who Joseph was in Egypt. This suggests why God made Jeroboam, of the tribe of Ephraim, king over the northern kingdom of ten tribes known as the "house of Israel". It is also a pointer to why Lord Jesus said He was not sent but unto the lost sheep of the house of Israel (ten tribes), pointing to upon whom The Gospel would be accepted as a people outside of Jerusalem and the Jews who rejected Him.
One of the tribe of Ephraim becoming king of Israel (northern kingdom of ten tribes) is likewise similar to Joseph's plight. Ephraim and Manasseh were Joseph's sons, born to him in Egypt, so there is another link to prophecy. God's Birthright blessings fell upon Joseph, and then were transferred to Ephraim and Manasseh per 1 Chronicles 5. Nowhere else are we shown another transfer of God's Birthright after that, per His Word. This means even today, God's Birthright is still... to be upon Ephraim and his brother Manasseh.