Evolution of feathers, fur, and scales

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River Jordan

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Jan 30, 2014
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This is a really cool story. :)

A scientist walks into a pet store and sees a scaleless bearded dragon. Being curious, he buys it, takes it to his lab, and tells a grad student to sequence some of its DNA to see why it didn't have any scales. What they found ended up solving a long-standing evolutionary puzzle.

Solved: the mystery of where feathers, fur and scales come from

In a study published Friday in the journal Science Advances, Milinkovitch and his grad student, Nicolas Di-Po, report that the mutated gene that robbed the bearded dragon of its scales is the same gene that controls feather development in birds and fur in mammals. Although the three features look very different in adult animals, they start in the same place...

Early on in embryonic development, feathers and fur look startlingly similar – both begin as tiny, thick accumulations of cells on the skin known as anatomical placodes. This shared morphology indicates that the features have the same evolutionary roots, which would seem to make sense, since birds and mammals evolved from a common ancestor some 320 million years ago.

But that ancestor was also the predecessor of modern reptiles; in fact, reptiles and birds are far more closely related than birds and mammals. Yet reptile scales develop very differently than feathers and fur – or they seemed to, at any rate. Not a lot of scientists study reptile embryos, Milinkovitch noted ("model species" like fruit flies and mice tend to get most of the attention), but those who did generally couldn't find evidence of anatomical placodes...

That's where things stood when Di-Po began parsing the genome of the naked bearded dragon his adviser had brought back to the lab. He pinpointed the mutation that prevented scales from developing, only to discover that it was EDA – the same gene responsible for feathers and fur.

That prompted the duo to take a closer look at the embryos of normal bearded dragons during development. They realized that the tiny creatures did have anatomical placodes, they just appeared and dispersed differently than the versions biologists are accustomed to seeing in mammals and birds...

Eventually, he and Di-Po identified placodes in several species of snake, lizard and crocodile.

"They obviously inherited this from a common ancestor," Milinkovitch said.

"That makes sense, ecologically speaking, when you think about, 'what is the innovation of amniotes?' " he continued, using the term to describe creatures like reptiles, birds and mammals, whose fetuses develop in membrane-bound amniotic sac that allows their mothers to lay fertilized eggs on land (or nurture them inside the uterus, as most mammals do).

Unlike amphibians and lobe-finned fish, amniotes aren't anchored to water by the need to lay their eggs there. That meant it was worth investing in adaptations that allowed us to live entirely terrestrial lives, like skin or scales that keep us from drying out. Hundreds of millions of years after reptiles, birds, and mammals diverged from this original amniote, we are united by the outcomes of this innovation.

"They are extremely different morphologically, but if you look past that you can see the homology," Milinkovitch said. "That's the beauty of it."
I love stories like this where scientific discoveries are sort of stumbled on by a combination of happenstance and scientific curiosity.

Anyone who's interested can read the published paper here: The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes
 

Dcopymope

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In a study published Friday in the journal Science Advances, Milinkovitch and his grad student, Nicolas Di-Po, report that the mutated gene that robbed the bearded dragon of its scales is the same gene that controls feather development in birds and fur in mammals. Although the three features look very different in adult animals, they start in the same place...


In a study published Friday in the journal Science Advances, Milinkovitch and his grad student, Nicolas Di-Po, report that the mutated gene that robbed the bearded dragon of its scales is the same gene that controls feather development in birds and fur in mammals. Although the three features look very different in adult animals, they start in the same place...

Early on in embryonic development, feathers and fur look startlingly similar – both begin as tiny, thick accumulations of cells on the skin known as anatomical placodes. This shared morphology indicates that the features have the same evolutionary roots, which would seem to make sense, since birds and mammals evolved from a common ancestor some 320 million years ago.

But that ancestor was also the predecessor of modern reptiles; in fact, reptiles and birds are far more closely related than birds and mammals. Yet reptile scales develop very differently than feathers and fur – or they seemed to, at any rate. Not a lot of scientists study reptile embryos, Milinkovitch noted ("model species" like fruit flies and mice tend to get most of the attention), but those who did generally couldn't find evidence of anatomical placodes...

That's where things stood when Di-Po began parsing the genome of the naked bearded dragon his adviser had brought back to the lab. He pinpointed the mutation that prevented scales from developing, only to discover that it was EDA – the same gene responsible for feathers and fur.

That prompted the duo to take a closer look at the embryos of normal bearded dragons during development. They realized that the tiny creatures did have anatomical placodes, they just appeared and dispersed differently than the versions biologists are accustomed to seeing in mammals and birds...

Eventually, he and Di-Po identified placodes in several species of snake, lizard and crocodile.

"They obviously inherited this from a common ancestor," Milinkovitch said.

"That makes sense, ecologically speaking, when you think about, 'what is the innovation of amniotes?' " he continued, using the term to describe creatures like reptiles, birds and mammals, whose fetuses develop in membrane-bound amniotic sac that allows their mothers to lay fertilized eggs on land (or nurture them inside the uterus, as most mammals do).

Unlike amphibians and lobe-finned fish, amniotes aren't anchored to water by the need to lay their eggs there. That meant it was worth investing in adaptations that allowed us to live entirely terrestrial lives, like skin or scales that keep us from drying out. Hundreds of millions of years after reptiles, birds, and mammals diverged from this original amniote, we are united by the outcomes of this innovation. "They are extremely different morphologically, but if you look past that you can see the homology," Milinkovitch said. "That's the beauty of it."

So the same gene will share the same functions across different kinds of creatures and produce very different results. We have seen this occur across many different creatures before, so why this discovery is considered as some sort of breakthrough is beyond me. In contrast, we have also observed entirely different genes produce similar results in entirely different creatures, as well as genes that are similar between different creatures that produce entirely different results. Despite this, this somehow is still evidence of common ancestry? This non-sense of phylogenetic homology is akin to convergent evolution, which is nothing more than an excuse given by the proponents of naturalism for the lack of evidence for common ancestry due to such factors as environmental differences. This article is a shining example that their conclusions are based on philosophical grounds just as much as those for the intelligent design argument.

If its true that this occurred by evolutionary means, if phylogenetic homology is true, we would see some consistency between the genes that performs these functions between creatures to begin with, which we don't, nor do we see any actual addition of genetic information for evolution to occur in the first place. We only observe the removal of genes, reduplication of genes, or the increased amounts of the same information, but nothing new. So therefore, there logically has to be a cause beyond simple genetics, beyond simple naturalistic explanations as to why this is occurring. The intelligent design argument is the most viable assertion, particularity that of Christianity, which states that different creatures have similar features because of causality and intent that is of a supernatural origin, and nothing at all to do with common ancestry through chance mutations that results in modifications to the morphology of a creature over time. The only thing this article proves is how little they know about how life truly came about, and how foolish they make themselves look every time they boast of "new" evidence that is circumstantial at best as if its prima facie evidence of evolution.
 

River Jordan

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Jan 30, 2014
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Dcopymope said:
So the same gene will share the same functions across different kinds of creatures and produce very different results.
Sort of. This research shows that mammal, reptile, and bird embryos start off by making the same basic structures using the same genes, and that as each develops they modify those structures to form hair, scales, and feathers by differential regulation of those genes (in simple terms).


We have seen this occur across many different creatures before, so why this discovery is considered as some sort of breakthrough is beyond me.
It's a breakthrough because it answers a long-standing question in evolutionary biology, i.e., how mammalian hair and avian feathers evolved from reptilian scales. Now not only can we say that it happened, we can describe the genetic pathway by which it occurred.

In contrast, we have also observed entirely different genes produce similar results in entirely different creatures, as well as genes that are similar between different creatures that produce entirely different results. Despite this, this somehow is still evidence of common ancestry? This non-sense of phylogenetic homology is akin to convergent evolution, which is nothing more than an excuse given by the proponents of naturalism for the lack of evidence for common ancestry due to such factors as environmental differences. This article is a shining example that their conclusions are based on philosophical grounds just as much as those for the intelligent design argument.
I'm sure that's what you believe given your entirely biased approach to evolutionary biology. I mean, it's not like you were going to respond "Wow, what neat research", right? No matter what they published you would have made up some excuse to wave it away. As I explained before, that's mostly what creationism is about.



If its true that this occurred by evolutionary means, if phylogenetic homology is true, we would see some consistency between the genes that performs these functions between creatures to begin with, which we don't,
Um.....that's exactly what this paper is about.

nor do we see any actual addition of genetic information for evolution to occur in the first place.
Oh yay, I get to do this with another creationist! <_<

Let's see if you can answer.....what is "genetic information" and how are you measuring it?

We only observe the removal of genes, reduplication of genes, or the increased amounts of the same information, but nothing new. So therefore, there logically has to be a cause beyond simple genetics, beyond simple naturalistic explanations as to why this is occurring. The intelligent design argument is the most viable assertion, particularity that of Christianity, which states that different creatures have similar features because of causality and intent that is of a supernatural origin, and nothing at all to do with common ancestry through chance mutations that results in modifications to the morphology of a creature over time.
Ok, then name a biological structure or system you've determined to be "intelligently designed" and 1) explain how you determined it to be so, and 2) explain the mechanism by which it arose.

The only thing this article proves is how little they know about how life truly came about, and how foolish they make themselves look every time they boast of "new" evidence that is circumstantial at best as if its prima facie evidence of evolution.

When can we expect to see your rebuttal paper?
 

River Jordan

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Ah yes, the worldwide conspiracy against those poor creationists. Why...just look at the piles of arbitrary rejection letters from scientific journals they have!! Oh, wait...... :rolleyes:
 

shnarkle

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This is a really cool story. :)

A scientist walks into a pet store and sees a scaleless bearded dragon. Being curious, he buys it, takes it to his lab, and tells a grad student to sequence some of its DNA to see why it didn't have any scales. What they found ended up solving a long-standing evolutionary puzzle.

Solved: the mystery of where feathers, fur and scales come from


I love stories like this where scientific discoveries are sort of stumbled on by a combination of happenstance and scientific curiosity.

Anyone who's interested can read the published paper here: The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes
This is a really cool story. However, I'm sure that some ID proponent could just as easily come up with questions and descriptions presented within their worldview to explain it to show that ID is a fact, if not a compelling theory as well. That would be a really cool story as well. The problem with both scenarios is that although they each offer a wealth of explanatory power in their own rights, neither of them can conclusively present the data as proof of their respective theories. The thing that those presenting their respective theories don't recognize, except when it comes to any competing theory; is that the framework is what determines what questions are to be asked, which can only produce answers within that framework. As interesting and as compelling as this is, this isn't science; it's orthodoxy