For the reader, "carcinogenicity" refers to cancer causing.
What most probably know is that anything we ingest does effect the organs of digestion. Stomach, gut, etc... Water soluble or not.
Case in point Vitamin C is water soluble. However, you still absorb the properties of Vitamin C when you ingest that supplement.
Below is another article and from Chemistry World.
Don't allow anyone to lead you to ignore the harmful effects of the Genotoxin Sucralose.
A compound formed when Splenda is consumed - and is even found in off-the-shelf sucralose - is suspected to be genotoxic
www.chemistryworld.com
"...
The researchers from North Carolina State University and the University of North Carolina at Chapel Hill concluded that the trace amounts of sucralose-6-acetate in a single, daily sucralose-sweetened drink exceeded the safe threshold of 0.15µg per person per day that the European Food Safety Authority has set. That doesn’t even factor in the sucralose-6-acetate could be produced during metabolism, the researchers noted.
Further, the team discovered that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity. ‘It’s time to revisit the safety and regulatory status of sucralose, because the evidence is mounting that it carries significant risks,’ warned
Susan Schiffman, the study’s corresponding author."