- Jan 30, 2014
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This is a really cool story. :)
A scientist walks into a pet store and sees a scaleless bearded dragon. Being curious, he buys it, takes it to his lab, and tells a grad student to sequence some of its DNA to see why it didn't have any scales. What they found ended up solving a long-standing evolutionary puzzle.
Solved: the mystery of where feathers, fur and scales come from
Anyone who's interested can read the published paper here: The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes
A scientist walks into a pet store and sees a scaleless bearded dragon. Being curious, he buys it, takes it to his lab, and tells a grad student to sequence some of its DNA to see why it didn't have any scales. What they found ended up solving a long-standing evolutionary puzzle.
Solved: the mystery of where feathers, fur and scales come from
I love stories like this where scientific discoveries are sort of stumbled on by a combination of happenstance and scientific curiosity.In a study published Friday in the journal Science Advances, Milinkovitch and his grad student, Nicolas Di-Po, report that the mutated gene that robbed the bearded dragon of its scales is the same gene that controls feather development in birds and fur in mammals. Although the three features look very different in adult animals, they start in the same place...
Early on in embryonic development, feathers and fur look startlingly similar – both begin as tiny, thick accumulations of cells on the skin known as anatomical placodes. This shared morphology indicates that the features have the same evolutionary roots, which would seem to make sense, since birds and mammals evolved from a common ancestor some 320 million years ago.
But that ancestor was also the predecessor of modern reptiles; in fact, reptiles and birds are far more closely related than birds and mammals. Yet reptile scales develop very differently than feathers and fur – or they seemed to, at any rate. Not a lot of scientists study reptile embryos, Milinkovitch noted ("model species" like fruit flies and mice tend to get most of the attention), but those who did generally couldn't find evidence of anatomical placodes...
That's where things stood when Di-Po began parsing the genome of the naked bearded dragon his adviser had brought back to the lab. He pinpointed the mutation that prevented scales from developing, only to discover that it was EDA – the same gene responsible for feathers and fur.
That prompted the duo to take a closer look at the embryos of normal bearded dragons during development. They realized that the tiny creatures did have anatomical placodes, they just appeared and dispersed differently than the versions biologists are accustomed to seeing in mammals and birds...
Eventually, he and Di-Po identified placodes in several species of snake, lizard and crocodile.
"They obviously inherited this from a common ancestor," Milinkovitch said.
"That makes sense, ecologically speaking, when you think about, 'what is the innovation of amniotes?' " he continued, using the term to describe creatures like reptiles, birds and mammals, whose fetuses develop in membrane-bound amniotic sac that allows their mothers to lay fertilized eggs on land (or nurture them inside the uterus, as most mammals do).
Unlike amphibians and lobe-finned fish, amniotes aren't anchored to water by the need to lay their eggs there. That meant it was worth investing in adaptations that allowed us to live entirely terrestrial lives, like skin or scales that keep us from drying out. Hundreds of millions of years after reptiles, birds, and mammals diverged from this original amniote, we are united by the outcomes of this innovation.
"They are extremely different morphologically, but if you look past that you can see the homology," Milinkovitch said. "That's the beauty of it."
Anyone who's interested can read the published paper here: The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes