No we cannot thwart God's plan. Your problem my friend may be in failing to see what God 's plan is.
God gave men a choice: to do things His Way or not.
God made men with the ability to move against Him. To do so is not wise, but the first unwise choice made in scripture was with Adam and Eve when they decided to go their own way instead of God's. The offspring of Adam and Eve have similarly been making unwise choices continuously ever since.
God wants people to love Him and to live loving Him when they have other alternatives. All men have gone with the alternatives. Are they all continuing to choose those unwise alternatives? There are some few exceptions!
Jesus was sent to allow men the option of going back and doing better than Adam and Eve did at the beginning. The possibility exists now because of Jesus and the Holy Spirit, but it must be chosen by men.
Choosing is only the beginning. Men cannot make it to the end of his allotted time, his course, on the Lord's side, all alone, but by choosing the way of God and continuously yielding the lead of themselves to the Holy Spirit thus opening the Way for God to provide the needed help.
God in His plan limited Himself by His own Word. Man, while he has time, has the option of removing the limitation on God... but the following verse shows how it has been too often and also is today in spite of the sacrifice of Jesus:
"Yea, they turned back and tempted God, and limited the Holy One of Israel." Psalm 78:41