Is. 53:2 isn't about Jesus's physical appearance. Isaiah couldn’t have been prophesying, in part, that Christ would be physically ugly for a few reasons: (I) saying that someone will be rejected for being ugly doesn’t serve a meaningful purpose temporally or spiritually as a prophecy, (II) a lack of mention regarding physical appearance shouldn’t be taken as meaning the person being spoken about is automatically “ugly”, and (III) if Isaiah, a prophet of God, was saying that Christ will be ugly, then surely one of God's many disciples, especially of the women, or any of His twelve apostles, would’ve said something about Christ being so ugly as to be partially rejected and killed over it as well. But they didn’t…
The meaning of "He hath no form nor comeliness; and when we shall see him, there is no beauty that we should desire him" (Is. 53:2) is this: To those who know Me not, there is in Me nothing to appeal to them, or to attract them. To those who know Me there is nothing more to be desired. “No beauty they could desire Him.”
He invites each person to draw very near to Him. To see Him as He really is, that ever they may have the joy of finding in Him all they could desire. The fulfillment of all they could desire in Master, Lord, or Friend.