A search for the word "appointed times" in the Bible yielded virtually no references to the Sabbath (I wasn't able to do an exhaustive search) and appeared to me to be a rabbit hole.
No rabbit hole, promise.
The word in
Mark 2:27 for "made" - "the Sabbath was made", 'eg
eneto'<'g
inomai' has the meanings of "create", "establish", "constitute", and "solemnise", even "keep" and "celebrate".
And similarly the word in Acts 17:31 for "appointed" - 'h
estehsen'<'h
istehmi' - has the meanings of "stand fast", "establish", "institute", "be permanent", "validated", "immovable", "unimpaired", "dignified".
Reading the whole of Acts 17 the creation of God and the beginnings of everything are clear and unmistakable.
"God created them man and wife" -- that constituted 'marriage', <always>. "God created / hallowed / appointed them man and wife".
And thus the day in which God would raise Christ up from the dead, similarly had been established and instituted and constituted and confirmed "from the beginning". "Christ the Beginning of the creation of God".
WHICH ONLY "DAY" EVER HAS THUS BEEN GIVEN "DIGNITY", “VALIDITY”, HAS THUS BEEN "HONOURED", HAS THUS BEEN "UNIMPAIRED" AND "KEPT HIGH" : BY GOD :
Genesis 2:2-3 Mark 2:27,28
Isaiah 58:13 compare 57:15!
WHERE do we see Lord and Sabbath exalted as in the Resurrection of Jesus Christ from the dead in Ephesian 1:19,20
Matthew 28:1-4 Hebrews 4:4-9, "GOD THUS CONCERNING THE SEVENTH DAY SPEAKING" BY THE WORD MADE FLESH FROM GLORY TO GLORY FOREVERMORE!?
An "unknown God" can neither be trusted, served nor worshipped...Something more than a theoretical knowledge of God is needed by us. Acts 17 --- verse 31. Something of God is necessary for us : the things "GOD APPOINTED"--"THE MAN .. THE DAY".