The lesson we must learn after we have reached the stage of illumination, is how to walk in the Spirit and not in the flesh, to see everything through spiritual eyes and not through fleshy eyes. This includes the part of the flesh which is our 'humanness', like our instincts that God has given us. For example, the will to live and protect ourselves.
All must be submitted to the leading of the Holy Spirit so all of our impulses come from Him alone. This was part of the testing that Jesus went through in the wilderness. Satan tempted Him to eat, which is not a sin, being the method by which we live, but He was on an inspired fast.
This a the big problem for me, I would interpret rejection from others, as a repeat from my childhood experiences and my emotions would go astray, instead of knowing that, as a child of God satan would use this against me and stop me hearing God's voice through it.
We must learn that we were bought at a great price, and God has every right to decide on our circumstances by allowing them, knowing the bigger picture of what He wants to achieve through us. It is about His glory not our own little lives and extending the kingdom.
Job made this problem when he was presented with his God departing from him (in his eyes) after such a closeness with Him. The heavens were brass. All reason told him that he had sinned, and the voices around told him so, but there was no answer when he cried out 'show me where I have sinned'. When he learned his lesson, that he must allow God to 'come and go' as He pleased, which is the coming and going out of the blessing, that the lesson was learned and he was blessed with double of what he had before. It is so with us, but in the spiritual realm.
Once we depend on the flesh, we are then ready to 'fall' and sin. Sin always separates us from God.